Malaria

All malaria parasites infest red blood cells, and that is where they should be looked for. Typically, a Leishman stained smear of peripheral blood is usued to detect the parasite.

Falciparum malaria

Plasmodium falciparum, the causative agent of malignant malaria, is usually diagnosed by its characteristic 'falciform' (banana-shaped) gametocytes.

Banana shape gametocytes

Vivax malaria

The more common, vivax malaria, is diagnosed by its trophozoites and schizonts in blood. In peripheral smears, they might be found in abudance, or be quite rare.

Schizont

Florette shaped trophozoite

The parasite should not be confused with white blood cells or platelets.

MD path exam 2012

Slides from MD Path exam held at my hospital.

Atrophy? LSIL? More like the former.

The jigsaw in the dermis. A cylindroma from scalp.

The customary storage disease slide from liver

Looks like crumpled tissue

Bone marrow with lot of macrophages

which are devouring RBCs. Hemophagocytic lymphohistiocytosis.

Skin

Strain your eyes to see the pink granules in between cells. Round fungi, possibly histoplasma.

The proceedings

Hemolysis. History suggestive of microangiopathic hemolytic anemia.

Mixed cellularity Hodgkins

Neuroendocrine neoplasm. Breast

A thyroid well dermarcated thyroid lesion, with pigmented regions

Pigmented medullary carcinoma (!)

Plamsacytoid cells in PBS but with an open nucleus

Plasmablastic leukemia?

Minor salivary gland. Polymorphous low grade adenocarcinoma.

Lymph node.

Lot of macrophages.

Emperipolesis (em = inside, peri=around, polemal = wander about)

Rosai Dorfman disease

Testis FNAC

Tigroid background; large round cells with streaked out chromatin

Classical seminoma

Ovary

Transitional carcinoma ovary

Solid nests of cells

Papillae with vascular core

Transitional ?

Borderline mucinous cystadenoma

Serous papillary carcinoma

Psammoma bodies