Rosai Dorfman disease

Sinus histiocytosis with massive lymphadenopathy

This disease stands out in the pantheon of weirdness: monocytes and macrophages attacking one's own lymph nodes, but not quite able to finish the job. The node remains in a stalemate.

Lymphocytes engulfed by macrophages ... 

... but not quite digested

... because they are 'self', after all

a phenomenon called 'emperipolesis'

Lymph node mostly replaced by pink macrophages

with reisdual blue lymphoid follicles

Granulomatous lymphadenitis with giant cells

13m with intermittent fever and a rubbery, matted lymph node in neck. Numerous giant cells, foreign body type, lymphocytes and neutrophils.

A difficult lymph node

A lymph node. Disrupted architecture? Some extracapsular invasion, maybe?

 Are these lacunar/ mummified cells? Not sure.

Please comment.

Parasites

A filaria worm (adult) in cross section in a lymph node

Microfilaria in blood

Findings from a lymph node

The following cell came out of a lymph node FNAC

Am I looking at a dendritic cell? Maybe. Next, a centroblast, or is it?

And a tingible body macrophage