Showing posts with label histiocytosis. Show all posts
Showing posts with label histiocytosis. Show all posts

Friday, January 3, 2020

Rosai Dorfman disease

Sinus histiocytosis with massive lymphadenopathy

This disease stands out in the pantheon of weirdness: monocytes and macrophages attacking one's own lymph nodes, but not quite able to finish the job. The node remains in a stalemate.


Lymphocytes engulfed by macrophages ... 

... but not quite digested

... because they are 'self', after all

a phenomenon called 'emperipolesis'





Lymph node mostly replaced by pink macrophages

with reisdual blue lymphoid follicles








Next generation sequencing: Part 1

 Imagine solving a puzzle with 100 pieces, each piece a centimeter in size, something like this: The genome is considerably larger than this...