Sunday, January 14, 2018

Neuroendocrine neoplasms

Neuroendocrine carcinoma 

Carcinoid of small intestine

Trabecular and reticular pattern; not exactly insular


Slight insular pattern seen



Pancreas


Chromogranin



Vague 'cell balls' separated by capillaries

Lung





TTF1 - absent (i.e. not endodermal, unlike lung)

Synaptophysin


Chromogranin

Chromogranin 

Meningioma

Rhabdoid meningioma

More or less resembling rhabdomyo(skeletal muscle)-blasts




Benign breast lesions

Fibroadenoma

Pericanalicular fibroadenoma








Nipple adenoma




With squamous metaplasia
Microglandular adenosis


Rhabdomyosarcoma

Botryoid ('grape like' on gross ) rhabdomyosarcoma





Lymphomas

Anaplastic large cell lymphoma





Note embryoid ('hallmark') cells

Lymphoplasmacytic lymphoma of marrow










Next generation sequencing: Part 1

 Imagine solving a puzzle with 100 pieces, each piece a centimeter in size, something like this: The genome is considerably larger than this...