Wednesday, May 30, 2018

Keratoacanthoma

A symmetric crater in the skin filled with keratin (really low power, slide held over condenser)

With peripheral 'lipping' of keratinocytes
Usually in elderly, face-head-neck region, the crater is visible on gross. It is the smooth roundish outline of the lesion that distinguishes it from a squamous carcinoma (plus that there's no dysplasia in spite of cell enlargement towards the center)

Wednesday, May 2, 2018

Papillary carcinoma

Follicular variant

Finding one odd looking focus in a nodular goiter

Vague papillary-follicular architecture
Blank, overlapping nuclei; lining follicles with scalloped colloid

Cellular details; blank chromatin, crowding, but forming little follicles

Encapsulated papillary




Hepatitis C with cirrhosis

Cirrhosis in a patient with Hepatitis C

CT


FNAC - ? hepatocytes

Cirrhotic nodules with dense lymphoid infiltrate




Apoptotic cells

Steatosis


Tuesday, May 1, 2018

Basal cell carcinoma


Growth over cheeks; palisading and retraction artifacts; small round cells in nodules


Next generation sequencing: Part 1

 Imagine solving a puzzle with 100 pieces, each piece a centimeter in size, something like this: The genome is considerably larger than this...