Friday, January 3, 2020

Condyloma acuminatum

Condyloma acuminatum

Anal growth, usually due to human papillomavirus infection
Verucous hyperplasia




Koilocytes

Squamous cell carcinoma

Poorly differentiated squamous cell carcinoma

A growth over tonsil


Plemorphic spindle cells


Bizarre nuclei & mitotic figures



Looks almost like a pleomorphic sarcoma

Until you find this

A keratin pearl

Rosai Dorfman disease

Sinus histiocytosis with massive lymphadenopathy

This disease stands out in the pantheon of weirdness: monocytes and macrophages attacking one's own lymph nodes, but not quite able to finish the job. The node remains in a stalemate.


Lymphocytes engulfed by macrophages ... 

... but not quite digested

... because they are 'self', after all

a phenomenon called 'emperipolesis'





Lymph node mostly replaced by pink macrophages

with reisdual blue lymphoid follicles








Next generation sequencing: Part 1

 Imagine solving a puzzle with 100 pieces, each piece a centimeter in size, something like this: The genome is considerably larger than this...