Cytokine production by cytotoxic T cells
T cells stimulated with tubercular antigen show a visible increase in the proportion of interferon-gamma producing CD8+ T cells; (flow cytometric data, PE Cy5 = CD8, FITC = IFN gamma)
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| Before stimulation; note the very small fraction of cells above the horizontal line (i.e. those producing interferon) |
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| After stimulation; 2-4 % of cells have now been activated and moved above the line |
The CD8 negative cell population (i.e. left of the vertical line) are a mix of B cells and helper (CD4+) T cells; note that CD4+ T cells will also produce interferons, as seen in the top left quadrant.
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